Npertuzumab package insert pdf

Perjeta can result in subclinical and clinical cardiac failure manifesting as chf, and decreased lvef. Safety for more detailed information refer to the product package insert. In patients who achieve a cr or cri, the recommended total dose of besponsa is 1. Besponsa inotuzumab ozogamicin dosage and administration. Evaluate cardiac function prior to and during treatment. Contraception should be used while receiving herceptin and for 7 months after your last dose of herceptin. Va pharmacy benefits management services, medical advisory panel, and visn pharmacist executives. Safety and efficacy of rolapitant for prevention of chemotherapyinduced nausea and. Page 25 of 35 60 to 90 mlmin, n200 and moderate renal impairment clcr 30 to 60 mlmin, n71 were similar to those in patients with normal renal function clcr greater than 90 mlmin, n200. Keytruda is a medicine that may treat certain cancers by working with your immune system.

One week after the last weekly dose of herceptin, administer 6 mgkg as an iv infusion over 30. When using in combination with perjeta pertuzumab and docetaxel, consult product monographs for perjeta and docetaxel for further information on these drugs. Treatment of pregnant cynomolgus monkeys with pertuzumab. Grapefruit may also increase plasma concentrations of lapatinib and should be avoided. Pertuzumab perjeta national drug monograph december 2014.

No relationship between clcr and pertuzumab exposure was observed over the range of observed clcr 27 to 244 mlmin. Cardiopulmonary arrest and hypomagnesemia 1 indications and usage 1. Sections or subsections omitted from the full prescribing information are not listed full prescribing information warning. Studies in animals have resulted in oligohydramnios, delayed renal development, and death. Pertuzumab is indicated in combination with trastuzumab and docetaxel for the treatment of patients with her2positive metastatic breast cancer genentech, 2012. Perjeta pertuzumab 420 mg14 ml 30 mgml in a singleuse vial 4 contraindications none. No relationship between clcr and pertuzumab exposure. See full prescribing information for complete boxed warning. Herceptin may result in the death of an unborn baby or birth defects.

Alemtuzumab binds to cd52, a nonmodulating antigen that is present on the surface of essentially all b and t lymphocytes, a majority of monocytes, macrophages, and nk cells, and a subpopulation of granulocytes. Pertuzumab also called 2c4, trade name perjeta is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic her2positive breast cancer. Pertuzumab is a recombinant humanized monoclonal antibody that binds to subdomain ii of the extracellular part of the her2 protein thereby blocking its ability to form heterodimers with other. Cardiomyopathy and embryofetal toxicity see full prescribing information for complete boxed warning. Nerlynx is a kinase inhibitor indicated for the extended adjuvant treatment of adult patients with earlystage her2overexpressedamplified breast cancer, to follow adjuvant trastuzumabbased therapy. Herceptin is indicated, in combination with cisplatin and capecitabine or 5fluorouracil, for the treatment of patients with her2 overexpressing metastatic gastric or gastroesophageal junction. Pertuzumab has an approximate molecular weight of 148 kda. Keytruda can cause your immune system to attack normal organs and tissues in any area of your.

If patients must be coadministered, a strong cyp3a4 inhibitor, based on. Highlights of prescribing information initial dose of. Each singledose vial contains 420 mg of pertuzumab. Administer perjeta, trastuzumab, and docetaxel by intravenous infusion every 3 weeks. Weve made enrollment simpler, faster and more intuitive with some key changes to our forms. Pertuzumab in metastatic breast cancer pubmed central pmc. Ixempra ixabepilone dosing and administration guide. Please click here for important safety information, including boxed warning regarding hepatic impairment, and click here 2 for full prescribing information. Ixempra is a prescription medicine used to treat locally advanced or metastatic breast cancer when certain other medicines have not worked or no longer work. Empliciti is a slamf7directed immunostimulatory antibody indicated in combination with lenalidomide and dexamethasone for the treatment of adult. Abraxane is indicated for the firstline treatment of locally advanced or metastatic nonsmall cell lung cancer, in combination with carboplatin, in patients who are not candidates for curative surgery or. The initial perjeta dose is 840 mg administered as a 60minute intravenous infusion, followed every 3 weeks thereafter by 420 mg administered as a 30 to 60 minute intravenous infusion. Please see indication and important safety information. Halaven is a prescription medicine used to treat adults with breast cancer that has spread to other parts of the body, and who have already received other types of anticancer medicines after the cancer.